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Resistant Depression

How well is your depression treatment working? Does it help, but not enough -- and you still don’t feel as well as you used to? Or is your depression treatment simply not working at all?

If so, you could have treatment-resistant depression, also called refractory depression. Unfortunately, depression treatments don’t always work. As many as two-thirds of people with depression aren’t helped by the first antidepressant they try. Up to a third don’t respond to several attempts at treatment.

Treatment-resistant depression can leave you hopeless. Months or even years can go by without any relief. And after the effort it took to get help, it can be demoralizing when you’re just not getting better. But if your depression treatment isn’t working, don’t give up. Many people can get their treatment-resistant depression under control. You and your doctor just need to find the right approach. This might include different drugs, therapy, and other treatments. If you’re still struggling with depression despite treatment, here’s what you need to know.

Understanding Treatment Resistant-Depression

What is treatment-resistant depression? Surprisingly, that can be hard to answer. Experts still disagree on what exactly the term means. Many say that it’s a case of depression that doesn’t respond to two different antidepressants from different classes. Other experts say that a person needs to try at least four different treatments before depression can be truly considered treatment-resistant. Of course for you, the exact definition doesn’t matter. You just need to ask yourself some basic questions.

Has your treatment failed to make you feel better?
Has your treatment helped some, but you still don’t feel like your old self?
Have the side effects of your medication been hard to handle?

If the answer is yes to any of these, you need to see your doctor. Whether or not you actually have treatment-resistant depression, you need expert help.


During an episode of schizophrenia, you may need to stay in the hospital for safety reasons.

Psychiatrist Disorders

  • Schizophrenia
  • Relationship Problems
  • Sexual-Addiction
  • Mania
  • Anxiety
  • Recurrent Depression
  • Resistant-Depression

Human Psychology

  • Development Psychology
  • Child Psychology
  • Family Psychology
  • Nubile Psychology
  • Old Age Psychology